Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

Mbah, James A. and Ayimele, Godfred A. and Eyonganyoh, Elvis N. and Nfor, Emmanuel N. (2017) Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone. International Journal of Organic Chemistry, 07 (02). pp. 83-90. ISSN 2161-4687

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Official URL: https://doi.org/10.4236/ijoc.2017.72007

Abstract

A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.

Item Type:	Article
Subjects:	EP Archives > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	08 Mar 2023 07:45
Last Modified:	25 Jul 2024 07:26
URI:	http://research.send4journal.com/id/eprint/961

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