Rei Yan, Sun Liu and Wakasuqui, Felipe and Du, Xiaochen and Groves, Matthew R. and Wrenger, Carsten (2021) Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus. Frontiers in Chemistry, 9. ISSN 2296-2646
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Abstract
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.
Item Type: | Article |
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Subjects: | EP Archives > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 23 Dec 2022 04:07 |
Last Modified: | 24 May 2024 05:21 |
URI: | http://research.send4journal.com/id/eprint/502 |