Delise, Pietro and Rivetti, Luigi and Poletti, Giuseppe and Centa, Monica and Allocca, Giuseppe and Sitta, Nadir and Cati, Arianna and Turiano, Giovanni and Lanari, Emanuela and Zeppilli, Paolo and Sciarra, Luigi and Severino, Paolo (2021) Clinical and Prognostic Significance of Idiopathic Left Bundle-Branch Block in Young Adults. Cardiology Research and Practice, 2021. pp. 1-7. ISSN 2090-8016
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Abstract
Aims. LBBB is rare in healthy young adults, and its long-term prognosis is uncertain. Methods. 56 subjects (aged <50 years), in whom an LBBB was discovered by chance in the absence of clinical and echocardiographic evidence of heart disease, were collected in a multicenter registry. Results. 69% were males. Mean age at the time of discovery of LBBB was 37 ± 11 years. Mean QRS duration was 149 ± 17 m sec and 35% had left axis deviation. All patients had a normal echocardiogram, except for left ventricular dyssynchrony; 37 patients underwent coronary angiography (30) or myocardial scintigraphy during effort Eriksson and Wilhelmsen (2005), and in all cases obstructive coronary artery disease was excluded. In 2/30 patients who underwent coronary angiography, an anomalous origin of the CX artery from the right coronary sinus was found. Thirty patients underwent cardiac magnetic resonance; in 60% it was normal, while in 40% it revealed late enhancement, which in 33% was localized in the basal septum, suggesting fibrosis of the left bundle branch. During follow-up (12+/10 years, median 10 years) no sudden death occurred. At the end of follow-up, all patients were alive, except for one who suffered accidental death. Two patients (3.5%) underwent PM implantation owing to syncope. The echocardiogram at the end of follow-up revealed LV dysfunction in only one patient. Conclusions. In young adults without apparent heart disease, LBBB is a heterogeneous condition. In the vast majority of cases, the prognosis is good and no ventricular dysfunction occurs over time. However, as only 18% of our patients were aged >60 years at the end of follow-up, we cannot establish the prognosis in older age-groups.
Item Type: | Article |
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Subjects: | EP Archives > Energy |
Depositing User: | Managing Editor |
Date Deposited: | 28 Dec 2022 05:38 |
Last Modified: | 11 Mar 2024 04:57 |
URI: | http://research.send4journal.com/id/eprint/447 |