Possible Effect of Cinnamomum camphora on Pain Amelioration and Pain Threshold in Mechanically Induced Pain in Female Wistar Rats

Background: Camphor, a long-standing chemical used in various home treatments, has been extensively studied for its antibacterial, antipruritic, and contraceptive properties, and is a key ingredient in topical home treatments. The study investigated the possible effect of Cinnamomum camphora essential oil on pain amelioration and pain threshold in mechanically induced pain in female Wistar rats.

Method: the study involves 25 adult Wistar rats, divided into five groups and each group was administered different milliliters of Cinnamomum camphora, except for group 1, pains were induced in the rats via experimental procedure; passive avoidance, paw withdrawer test, and tail clip test. Data obtained were analyzed using IBM SPSS version 23.

Results: Group 2 showed a significant increase in avoidance time, a significant increase in pain threshold, and a significant decrease in pain sensitivity compared to the control group. The reverse was the case of group 4 when compared to the control group. Interestingly, the effects of C. camphora oil were more on the low-dose group than on the high-dose group.

Conclusion: These results suggest that C. camphora has an analgesic effect and is dose-dependent.