Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15

Kang, Fenghua and Lu, Xiuxiang and Zhang, Sha and Chen, Dekun and Kuang, Min and Peng, Weiwei and Tan, Jianbing and Xu, Kangping and Zou, Zhenxing and Tan, Haibo (2021) Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15. Frontiers in Chemistry, 9. ISSN 2296-2646

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Official URL: https://doi.org/10.3389/fchem.2021.755351

Abstract

Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC50 values ranging from 3.6 to 15.8 μM.

Item Type:	Article
Subjects:	EP Archives > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	13 Dec 2022 09:51
Last Modified:	14 Sep 2023 09:18
URI:	http://research.send4journal.com/id/eprint/376

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