Study on Potential Drug Interactions between cART and New Psychoactive Substances

New hazardous drugs with unknown synthetic chemical structures or structures of known entities that
have been changed in order to avoid prosecution are flooding the European illegal drug market. Tons
of synthetic cannabinoids, synthetic phenylethylamine/cathinones or substances of rather rare
occurrence have been seized by authorities during the past years, which is believed to only the tip of
the iceberg. These substances are marketed as legal highs, often legally sold via internet structures
and especially consumed by very young people as party drugs. Their mechanisms of action,
hazardous side effect profile and potential drug-drug-interactions, especially with antiretrovirals, are
discussed in the following article.