Intricate Relationship of Oral Manifestations and Systemic Diseases

Oral cavity manifestations and systemic disease are associated with each other. The oral cavity can be affected by various diseases such as cardiovascular disease, gastrointestinal disease, hematologic disease, diabetes mellitus, metabolic disorders, obesity, and neurologic disease. Treatment of some systemic disease also causes oral lesions. These include cancer treatment and other medications that result in salivary compromise.