Analyzing the Impact of Long-Lasting Changes Neurodegeneration and Role of Nutriention among Various Age Groups

The process of nutritional programming in the hypothalamus is based on the several genes that regulated the metabolic process controlled by the hypothalamus. Studies conducted previously reported that the expression of genes that can be changed by the restriction of perinatal protein are usually involved in the metabolic processes regulation. The bioinformatics analysis of the study indicated that the restriction of perinatal protein alters the expression of two gene clusters that are responsible for regulating common cellular mechanisms. The first cluster of gene contains several gatekeeper genes that are associated with the regulation of nutrient sensing and insulin signalling. On the other hand, the second cluster of gene contains a functional network of co-regulators and nuclear receptors of transcription responsible for the use and detection of lipid nutrients as fuel. In this chapter indicated that there will be increase risks of acquiring diseases as a result of irregular intake of diet. These dangers include an increased risk of diseases like liver abnormalities, hypertension, lipid deposition, and others. It has also been analysed in the present study that the energy homeostasis and nutrient sensing controlled by the hypothalamus can be affected by the perinatal protein restriction which may result in the long-lasting changes in the several metabolic pathways.