BMI and Circulating Adipocytokine Markers in Insulin Resistance Females with Type 2 Diabetes

The present study intends to assess how Insulin Resistance females with Type 2 diabetes' levels of resistine, fasting blood glucose, and adiponectin compared to their BMI. Obesity has emerged as a public health crisis in many populations including Sudanese. Adipose tissue produces several adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. A total of 205 Sudanese women between the ages of 35 and 64 were recruited to participate in this descriptive cross-sectional study. Adiponectin and resistine concentrations were determined by ELISA Kits, and plasma levels of blood glucose were determined by using the particle-enhanced immunoturbidimetric assay method Cobas C-311®. Observed from these results significant difference between the means of fasting blood glucose (FBG), adiponectin, resistine and BMI classified according to WHO body mass index classification (underweight, healthy weight, overweight, obesity and sever obesity). In this study, the results show strong negative Correlation between the levels of serum Adiponectin and Fasting Blood Glucose. (P.value = 0.013, r = -7.9), Adiponectin and Resistine. (P.value = 0.019, r = -6.6). In the other side strong positive Correlation between the levels of serum Resistine and Fasting Blood Glucose. (P.value = 0.015, r = 6.0). Observed from this results negative Relationship between the mean of BMI compared with the history of the patient/ years.

The study revealed that BMI had an impact on the levels of adipocytokines and increased the risk of insulin resistance in females with Type 2 diabetes by increasing the level of resistin, fasting blood glucose, and reducing adiponectin in various groups classified according to WHO body mass index (BMI) classification.