Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity

Alfarouk, Omar R. and Barakat, Ahmed B. and Shoman, Sahar A. and Ghanem, Husam A. and Ali, Mohamed A. and Rashad, Aymn E. (2013) Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity. Egyptian Academic Journal of Biological Sciences, G. Microbiology, 5 (1). pp. 25-33. ISSN 2090-0880

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Official URL: https://doi.org/10.21608/eajbsg.2013.16642

Abstract

Thirteen chemical compounds belonging to the fused heterocyclic pyrimidines were synthesized and screened in order to assay their antiviral activity against the avian influenza virus (H5N1) A/Chicken/Qalubiya/1/2006(H5N1) by plaque reduction assay on MDCK cells. All tested compounds were non-toxic on the cells. Ten out of thirteen compounds (10, 13, 9, 12, 1, 11, 7, 8, 3 and 4) showed moderate percentage of inhibition respectively at concentration 20 μg/ml while the remaining three compounds (5, 2 and 6) showed weak inhibitory activity respectively at same concentration.

Item Type:	Article
Subjects:	EP Archives > Biological Science
Depositing User:	Managing Editor
Date Deposited:	12 Jul 2023 03:36
Last Modified:	29 Sep 2023 12:42
URI:	http://research.send4journal.com/id/eprint/2509

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