Effect of Plasma-leptin on Cardiac Disorders with Type 2 Diabetes-patients

Background: The net mechanism by which visceral fat concentration is still unclear because of its interference with autonomic dysfunction which could be simply modified by leptin through the dorosomedical hypothulumus. This work studies the potential correlations between visceral fat concentration, cardiac autonomic dysfunction having diabetic disorder (type 2) and leptin.

Methods: The present work includes 90 cases with cardiovascular risk parameters and diabetic patients and 90 (age- and gender-matched) non diabetic. Typical measurements for cardiovascular risk factors have been measured in addition to plasma visceral fat area, heart variability, leptin and soluble leptin receptor standards.

Results: Visceral fat area is highly inversely dependant on the parameters of heart rate variability (p < 0.05 and standard deviations of NN (normal RR) intervals during the 24-hour period r = - 0.239, p =0.003.Similarly, the plasma standard of leptin is also important (p < 0.05) showing reverse dependence with the parameters of heart rate variability standard deviations of NN (normal RR) intervals during the 24-hour period r = -0.238, p = 0.017. In case of non diabetic patients, there are almost zero dependence between leptin and any of heart rate variability parameters.

Conclusions: Patients having visceral obesity and type 2-diabetes are strongly affected with hyper-leptinemia which may lead to cardiac autonomic dysfunction.