Combined Detection of Urinary Micro Albumin, α1‑microglobulinand N-acetyl-β-D-glucosaminidase in the Early Diagnosis of Diabetic Nephropathy

Objective: To analyze the values of combined detection of urinary micro albumin (mAlb), α1‑microglobulin (α1-MG) and N-acetyl-β-D-glucosaminidase (NAG) in the early diagnosis of diabetic nephropathy (DN).

Methods: Ninety-four patients with early DN who were admitted to the hospital between April 2015 and April 2016 were selected and set as a DN group. Moreover, seventy-six patients with diabetes who were admitted to the hospital in the same period were selected and set as a diabetes group, and sixty-four healthy people were selected as set as a control group. The urinary mAlb, α1-MG and NAG of the three groups were detected. Moreover, the patients were divided into a favorable blood glucose control group and a poor blood glucose control group according to the blood glucose control condition of the patients. The detection results of the three groups were compared and statistically analyzed.

Results: The urinary mAlb, α1-MG and NAG levels of the DN group were significantly higher than those of the diabetes group and control group, and the differences had statistical significance (P<0.05). The detection indicator values of the favorable blood glucose control group were much lower than those of the poor blood glucose control group, and the difference was statistically significant (P<0.05). The positive rate of the combined detection of mAlb, α1-MG and NAG levels was 90.2%, which was much higher than that of single indicator (P<0.05).

Conclusion: Combined detection of urinary mAlb, α1-MG and NAG is sensitive in diagnosing early renal damages in DN patients.