Differential Pressure, P_D, Capital Parameter in the Determination of Cardiac Health and Prominent Kinetic Indicator of Drugs in the Blood

Background: this work is a suite of previous articles where it has been demonstrated that if the differential pressure remains constant, it allows when it is multiplied by cardiac frequency to determine the volumic cardiac power (KUNYIMA equation). Also it has afforded to calculate differential enthalpy ( that is exothermic energy in ejection fraction. In KUNYIMA Formula the differential pressure has allowed to assess in satisfactory way one part of total energy from cellular metabolism (Keith-Flack node) which enable the heart blood to circulate in the organism. In KUNYIMA relations, made possible the calculation of cardiac exergetic yield nowadays unrecognized by researchers, different from volumic yield defined by ejection fraction. This cardiac exergetic yield has been assimilated to the heart longevity.

Aim and objective: this work gives in detail mathematical useful expressions, rational approaches to be followed when differential pressure substantially changes, for example when the blood contains an injected drug at initial concentration and when the kinetic of this drug should be followed.

Methodology: Calculations have been our methodology using compartmental analysis.

Results: It is shown hereby the use of differential equations in the determination of kinetic parameters

Conclusion: Physical Cardiochemistry is improved with new theory.